Grotesques, Caricatures and the Clever Mice at Pistiros

The article discusses a selection of five particular pieces from the 27 sealings found at Pistiros in Bulgaria in 2012, most of them with two imprints, apparently attached to Ear Cleaner a document with a contract or a deal.Subjects represented on the seals discussed here show grotesques, caricatures and mice acting as humans.They reflect a specifi

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Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer

Abstract Despite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear.Here, imaging mass cytometry of tumor tissues from ICB-treated patients identifies a distinct cell population of CD39+PD-1+CD8+ T cells, specifically the TCF1+ subset,

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